Single-nucleotide polymorphism in the promoter region of the osteopontin gene at nucleotide− 443 as a marker predicting the efficacy of pegylated interferon/ribavirin …

OG Shaker, NAH Sadik, A El-Dessouki - Human Immunology, 2012 - Elsevier
Osteopontin (OPN) is an extracellular matrix glycophosphoprotein produced by several
types of cells including the immune system. The present study examined the possibility that
single-nucleotide polymorphisms (SNP) in the promoter region of the OPN at nt− 443 is a
marker predicting the therapeutic efficacy of pegylated interferon (peg-IFN-α2b)–ribavirin
combination therapy in Egyptian patients with chronic hepatitis C. Blood was collected from
95 patients with chronic hepatitis C who had received peg-IFN-α2b–ribavirin combination …
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