Social defeat-induced Cingulate gyrus immediate-early gene expression and anxiolytic-like effect depend upon social rank

AH Basil, M Gross, R Rajkumar, M Kirby… - Brain Research …, 2018 - Elsevier
Social hierarchy is considered to impart an adaptive advantage to the species by reducing
long-term conflict between conspecifics. While social stratification is frequently established
via stress-inducing stimuli, the subsequent integration of individuals into the hierarchy may
attenuate anxiety. Presently, we hypothesized that repeated reinforcement of murine social
hierarchy in the dominant-submissive relationship (DSR) food-competition test would
engender divergent neuroplastic changes mediating both social and anxiety-like behavior …
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