Somatostatin and water excretion in man: an intrarenal action
BJ Walker, PA Evans, ML Forsling… - Clinical …, 1985 - Wiley Online Library
BJ Walker, PA Evans, ML Forsling, GA Nelstrop
Clinical endocrinology, 1985•Wiley Online LibraryIntravenous infusion of somatostatin in six water loaded normal human subjects produced a
prompt reduction in urine flow accompanied by a rise in urine osmolality and a decrease in
free water clearance. Plasma AVP levels did not change. Somatostatin would seem to exert
an antidiuretic effect directly on the kidney.
prompt reduction in urine flow accompanied by a rise in urine osmolality and a decrease in
free water clearance. Plasma AVP levels did not change. Somatostatin would seem to exert
an antidiuretic effect directly on the kidney.
Summary
Intravenous infusion of somatostatin in six water loaded normal human subjects produced a prompt reduction in urine flow accompanied by a rise in urine osmolality and a decrease in free water clearance. Plasma AVP levels did not change. Somatostatin would seem to exert an antidiuretic effect directly on the kidney.
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