Spermine and spermidine are cytotoxic towards intestinal cell cultures, but are they a health hazard at concentrations found in foods?
Spermine and spermidine are polyamines (PA) naturally present in all organisms, in which
they have important physiological functions. However, an excess of PA has been associated
with health risks. PA accumulates at quite high concentrations in some foods, but a
quantitative assessment of the risk they pose has been lacking. In the present work, the
cytotoxicity of spermine and spermidine was evaluated using an in vitro human intestinal cell
model, and employing real-time cell analysis. Both spermine and spermidine showed a …
they have important physiological functions. However, an excess of PA has been associated
with health risks. PA accumulates at quite high concentrations in some foods, but a
quantitative assessment of the risk they pose has been lacking. In the present work, the
cytotoxicity of spermine and spermidine was evaluated using an in vitro human intestinal cell
model, and employing real-time cell analysis. Both spermine and spermidine showed a …
Spermine and spermidine are cytotoxic towards intestinal cell cultures, but are they a health hazard at concentrations found in foods?
B Río Lagar, B Redruello, D Martínez Linares… - 2018 - digital.csic.es
Spermine and spermidine are polyamines (PA) naturally present in all organisms, in which
they have important physiological functions. However, an excess of PA has been associated
with health risks. PA accumulates at quite high concentrations in some foods, but a
quantitative assessment of the risk they pose has been lacking. In the present work, the
cytotoxicity of spermine and spermidine was evaluated using an in vitro human intestinal cell
model, and employing real-time cell analysis. Both spermine and spermidine showed a …
they have important physiological functions. However, an excess of PA has been associated
with health risks. PA accumulates at quite high concentrations in some foods, but a
quantitative assessment of the risk they pose has been lacking. In the present work, the
cytotoxicity of spermine and spermidine was evaluated using an in vitro human intestinal cell
model, and employing real-time cell analysis. Both spermine and spermidine showed a …
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