Spinal motor neuronal degeneration after knee joint immobilization in the guinea pig
X He, V Dishman - Journal of manipulative and physiological therapeutics, 2010 - Elsevier
OBJECTIVE: This study used a unilateral knee joint immobilization model in adult guinea
pigs to test the hypothesis that retrograde degeneration of motor neurons in the spinal cord
is the result of attenuation of knee joint activities. METHODS: A total of 32 adult guinea pigs
were used and divided into 8 groups based on the duration of knee joint immobilization.
Light microscopic studies of Nissl, nitric oxide synthase immunohistochemistry, horseradish
peroxidase, and fast blue were carried out to examine the neurons in the spinal cord …
pigs to test the hypothesis that retrograde degeneration of motor neurons in the spinal cord
is the result of attenuation of knee joint activities. METHODS: A total of 32 adult guinea pigs
were used and divided into 8 groups based on the duration of knee joint immobilization.
Light microscopic studies of Nissl, nitric oxide synthase immunohistochemistry, horseradish
peroxidase, and fast blue were carried out to examine the neurons in the spinal cord …
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