[HTML][HTML] Src family kinase–mediated negative regulation of hematopoietic stem cell mobilization involves both intrinsic and microenvironmental factors

J Borneo, V Munugalavadla, EC Sims, S Vemula… - Experimental …, 2007 - Elsevier
OBJECTIVE: The intracellular signals that contribute to granulocyte colony–stimulating factor
(G-CSF) receptor induced stem cell mobilization are poorly characterized. METHODS: We
show enhanced G-CSF induced mobilization of stem cells in mice deficient in expression of
Src family kinases (SFK−/−), which is associated with hypersensitivity of SFK−/− bone
marrow cells to G-CSF as well as sustained activation of signal transducer and activator of
transcription-3. RESULTS: A proteome map of the bone marrow fluid derived from wild-type …
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