Strain differences in susceptibility to streptozotocin-induced diabetes: effects on hypertriglyceridemia and cardiomyopathy
Abstract Objective: Streptozotocin (STZ)-induced diabetes in Wistar rats results in severe
hyperlipidemia and a characteristic cardiomyopathy. However, Wistar-Kyoto (WKY) rats
made diabetic with a similar dose of STZ did not develop heart dysfunction or
hypertriglyceridemia at 12 weeks post-STZ. We investigated whether an apparent resistance
of the WKY strain to develop diabetic cardiomyopathy and hypertriglyceridemia following
chronic diabetes could be due to a reduced susceptibility to the diabetogenic effects of STZ …
hyperlipidemia and a characteristic cardiomyopathy. However, Wistar-Kyoto (WKY) rats
made diabetic with a similar dose of STZ did not develop heart dysfunction or
hypertriglyceridemia at 12 weeks post-STZ. We investigated whether an apparent resistance
of the WKY strain to develop diabetic cardiomyopathy and hypertriglyceridemia following
chronic diabetes could be due to a reduced susceptibility to the diabetogenic effects of STZ …
