Study of low-density lipoprotein receptor regulation by oral (steroid) contraceptives: desogestrel, levonorgestrel and ethinyl estradiol in JEG-3 cell line and placental …
G Ramakrishnan, A Rana, C Das, NC Chandra - Contraception, 2007 - Elsevier
BACKGROUND: The aim of this study was to compare in vitro the role of two oral
contraceptives, desogestrel (a less androgenic derivative of levonorgestrel) and
levonorgestrel—alone and in combination with ethinyl estradiol—on low-density lipoprotein
(LDL) receptor regulation by assessing receptor protein expression and functional
effectiveness. STUDY DESIGN: Placental tissue and cultured placental cells (JEG-3) were
used to study the expression and endocytotic activity of LDL receptor protein. The …
contraceptives, desogestrel (a less androgenic derivative of levonorgestrel) and
levonorgestrel—alone and in combination with ethinyl estradiol—on low-density lipoprotein
(LDL) receptor regulation by assessing receptor protein expression and functional
effectiveness. STUDY DESIGN: Placental tissue and cultured placental cells (JEG-3) were
used to study the expression and endocytotic activity of LDL receptor protein. The …
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