Styrene inhibits monoamine oxidase A, but not monoamine oxidase B in monkey brain mitochondria

T Egashira, F Takayama, K Sakai, Y Yamanaka - Toxicology letters, 2000 - Elsevier
The effects of styrene on mitochondrial monoamine oxidase (MAO) activity in rat and
monkey brains were compared in vitro. After preincubation at 25° C for 20 min with 1 mM
styrene monomer MAO-A activity in monkey brain was inhibited potently using 5-HT (for
MAO-A substrate), but MAO-B activity in monkey brain and platelets were slightly inhibited
using β-PEA (for MAO-B substrate). Styrene monomer also competitively inhibited MAO-A
activity in a dose-dependent manner. MAO-A in monkey brain was inhibited by styrene in …
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