Substance P and its role in neural mechanisms governing learning, anxiety and functional recovery
RU Hasenöhrl, MA De Souza-Silva, S Nikolaus… - Neuropeptides, 2000 - Elsevier
The neurokinin Substance P (SP) is widely distributed in the central nervous system and has
been extensively studied in various functional aspects. This review focuses on the
behavioral relevance of SP. Here we show that SP can have memory-promoting, reinforcing
and anxiolytic-like effects when administered systemically or into the nucleus basalis of the
ventral pallidum. These effects seem to be mediated via the SP-preferring NK1receptor and
differentially related to N-versus C-terminal fragments of the undecapeptide. Secondly, SP …
been extensively studied in various functional aspects. This review focuses on the
behavioral relevance of SP. Here we show that SP can have memory-promoting, reinforcing
and anxiolytic-like effects when administered systemically or into the nucleus basalis of the
ventral pallidum. These effects seem to be mediated via the SP-preferring NK1receptor and
differentially related to N-versus C-terminal fragments of the undecapeptide. Secondly, SP …
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