Substance P‐induced release of prostaglandins from astrocytes: regional specialisation and correlation with phosphoinositol metabolism
DR Marriott, GP Wilkin, JN Wood - Journal of neurochemistry, 1991 - Wiley Online Library
Addition of substance P (SP) to astrocytes cultured from rat neonatal spinal cord evoked a
time‐and concentration‐dependent increase in the accumulation of phosphoinositol and the
release of prostaglandin (PG) D2 and PGE2. Both basal and stimulated releases were
reduced to similar levels by indomethacin. In contrast, astrocytes cultured from cerebral
cortex and cerebellum showed no SP‐stimulated increase in phosphoinositol accumulation
or release of PGs. Release of PGD2 and PGE2 was, however, stimulated by the calcium …
time‐and concentration‐dependent increase in the accumulation of phosphoinositol and the
release of prostaglandin (PG) D2 and PGE2. Both basal and stimulated releases were
reduced to similar levels by indomethacin. In contrast, astrocytes cultured from cerebral
cortex and cerebellum showed no SP‐stimulated increase in phosphoinositol accumulation
or release of PGs. Release of PGD2 and PGE2 was, however, stimulated by the calcium …
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