[HTML][HTML] Survival impact of pre-treatment neutrophils on oropharyngeal and laryngeal cancer patients undergoing definitive radiotherapy
WA Sumner, WA Stokes, A Oweida… - Journal of Translational …, 2017 - Springer
Journal of Translational Medicine, 2017•Springer
Background Squamous cell carcinoma of the head and neck (HNSCC) represents an array
of disease processes with a generally unfavorable prognosis. Inflammation plays an
important role in tumor development and response to therapy. We performed a retrospective
analysis of HNSCC patients to explore the relationship of the lymphocyte and neutrophil
counts, the neutrophil-to-lymphocyte ratio (NLR) overall survival (OS), cancer-specific
survival (CSS), local control (LC) and distant control (DC). Materials/methods All patients …
of disease processes with a generally unfavorable prognosis. Inflammation plays an
important role in tumor development and response to therapy. We performed a retrospective
analysis of HNSCC patients to explore the relationship of the lymphocyte and neutrophil
counts, the neutrophil-to-lymphocyte ratio (NLR) overall survival (OS), cancer-specific
survival (CSS), local control (LC) and distant control (DC). Materials/methods All patients …
Background
Squamous cell carcinoma of the head and neck (HNSCC) represents an array of disease processes with a generally unfavorable prognosis. Inflammation plays an important role in tumor development and response to therapy. We performed a retrospective analysis of HNSCC patients to explore the relationship of the lymphocyte and neutrophil counts, the neutrophil-to-lymphocyte ratio (NLR) overall survival (OS), cancer-specific survival (CSS), local control (LC) and distant control (DC).
Materials/methods
All patients received definitive treatment for cancers of the oropharynx or larynx between 2006–2015. Neutrophil and lymphocyte counts were collected pre-, during-, and post-treatment. The correlations of patient, tumor, and biological factors to OS, CSS, LC and DC were assessed.
Results
196 patients met our inclusion criteria; 171 patients were Stage III or IV. Median follow-up was 2.7 years. A higher neutrophil count at all treatment time points was predictive of poor OS with the pre-treatment neutrophil count and overall neutrophil nadir additionally predictive of DC. Higher pre-treatment and overall NLR correlated to worse OS and DC, respectively.
Conclusion
A higher pre-treatment neutrophil count correlates to poor OS, CSS and DC. Lymphocyte counts were not found to impact survival or tumor control. Higher pre-treatment NLR is prognostic of poor OS.
Springer
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