Targeted delivery of mitomycin C-loaded and LDL-conjugated mesoporous silica nanoparticles for inhibiting the proliferation of pterygium subconjunctival fibroblasts
Pterygium is a degenerative disease that characterized by excessive fibrovascular
proliferation. To reduce the recurrence rate, surgery is the main strategy, in combination with
adjacent procedures or adjunctive therapy. One of the most common adjunctive agents,
mitomycin C (MMC), is known as an alkylating agent that inhibits fibroblast proliferation but
is limitedly applied in pterygium due to various complications. A previous study
demonstrated that activated pterygium subconjunctival fibroblasts overexpressed low …
proliferation. To reduce the recurrence rate, surgery is the main strategy, in combination with
adjacent procedures or adjunctive therapy. One of the most common adjunctive agents,
mitomycin C (MMC), is known as an alkylating agent that inhibits fibroblast proliferation but
is limitedly applied in pterygium due to various complications. A previous study
demonstrated that activated pterygium subconjunctival fibroblasts overexpressed low …
