[HTML][HTML] Tear film and ocular surface alterations in chronic users of antiglaucoma medications
LP Baffa, JRS Ricardo, AC Dias, CM Módulo… - Arquivos brasileiros de …, 2008 - SciELO Brasil
LP Baffa, JRS Ricardo, AC Dias, CM Módulo, AM Braz, JS Paula, MLV Rodrigues…
Arquivos brasileiros de oftalmologia, 2008•SciELO BrasilPURPOSE: Tear film can be altered by chronic medications that may disrupt the equilibrium
responsible for the functioning of the lacrimal gland and ocular surface. The purpose of this
study was to determine if antiglaucomatous chronic treatment induced alterations in the tear
film and ocular surface. METHODS: After informed consent, 21 patients using
antiglaucomatous eye drops for more than 8 months and 20 age-and sex-matched
volunteers without eye and systemic medications (control group) were enrolled. The data of …
responsible for the functioning of the lacrimal gland and ocular surface. The purpose of this
study was to determine if antiglaucomatous chronic treatment induced alterations in the tear
film and ocular surface. METHODS: After informed consent, 21 patients using
antiglaucomatous eye drops for more than 8 months and 20 age-and sex-matched
volunteers without eye and systemic medications (control group) were enrolled. The data of …
PURPOSE
Tear film can be altered by chronic medications that may disrupt the equilibrium responsible for the functioning of the lacrimal gland and ocular surface. The purpose of this study was to determine if antiglaucomatous chronic treatment induced alterations in the tear film and ocular surface.
METHODS
After informed consent, 21 patients using antiglaucomatous eye drops for more than 8 months and 20 age- and sex-matched volunteers without eye and systemic medications (control group) were enrolled. The data of ocular discomfort, fluorescein and lisamine green staining, tear film break-up time and Schirmer test were collected and compared by Student's t test. The impression cytology data were graded and compared by chi-square test.
RESULTS
Patients chronically using antiglaucomatous medications presented with significant higher fluorescein staining (p=0.003), lisamine green staining (p=0.02) and lower TFBUT (p=0.001). The other comparedparameters, including impression cytology were similar between the treated and control group (p>0.05).
CONCLUSIONS
The present study shows that the tear film and the ocular surface are altered in patients under antiglaucomatous medications. In common, all medications were preserved with benzalkonium chloride. Efforts to minimize the adverse effects of chronic use of antiglaucomatous drugs must be addressed.
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