Temporal development of genetic and metabolic effects of biotin deprivation. A search for the optimum time to study a vitamin deficiency

A Hernández-Vázquez, E Ochoa-Ruiz… - Molecular Genetics and …, 2012 - Elsevier
Biotin deficiency (Bt-D) is usually studied at the point at which the animal model exhibits the
signs of full-blown deficiency symptoms; in rats, this typically occurs at 6–8weeks of feeding
a deficient diet. To differentiate specific deficiency effects from those of undernutrition, biotin
sufficient and deficient rats were studied at 2, 3, 4, and 5weeks on the deficiency diet, before
the onset of weight loss and deficiency signs. The deficiency state was confirmed by
biochemical and molecular analyses. Blood and liver metabolites were determined and …

Temporal development of genetic and metabolic effects of biotin deprivation. A search for the optimum time to study a vitamin deficiency

H Vázquez - 2019 - repositorio.pediatria.gob.mx
Descripción:" La deficiencia de biotina (Bt-D) se suele estudiar en el momento en que el
modelo animal muestra los signos de síntomas de deficiencia total, en ratas, esto ocurre
típicamente a las 6-8 semanas de la alimentación de una dieta deficiente. Para diferenciar
la deficiencia específica Efectos de los de la desnutrición, la biotina suficiente y las ratas
deficientes se estudiaron a las 2, 3, 4 y 5 semanas en la dieta de deficiencia, antes de la
aparición de pérdida de peso y signos de deficiencia. El estado de deficiencia fue …
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