The ABC transporter ABC40 encodes a phenylacetic acid export system in Penicillium chrysogenum
SS Weber, A Kovalchuk, RAL Bovenberg… - Fungal Genetics and …, 2012 - Elsevier
The filamentous fungus Penicillium chrysogenum is used for the industrial production of β-
lactam antibiotics. The pathway for β-lactam biosynthesis has been resolved and involves
the enzyme phenylacetic acid CoA ligase that is responsible for the CoA activation of the
side chain precursor phenylacetic acid (PAA) that is used for the biosynthesis of penicillin G.
To identify ABC transporters related to β-lactam biosynthesis, we analyzed the expression of
all 48 ABC transporters present in the genome of P. chryso-genum when grown in the …
lactam antibiotics. The pathway for β-lactam biosynthesis has been resolved and involves
the enzyme phenylacetic acid CoA ligase that is responsible for the CoA activation of the
side chain precursor phenylacetic acid (PAA) that is used for the biosynthesis of penicillin G.
To identify ABC transporters related to β-lactam biosynthesis, we analyzed the expression of
all 48 ABC transporters present in the genome of P. chryso-genum when grown in the …
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