The biology of prostaglandins and their role as a target for allergic airway disease therapy
K Lee, SH Lee, TH Kim - International journal of molecular sciences, 2020 - mdpi.com
Prostaglandins (PGs) are a family of lipid compounds that are derived from arachidonic acid
via the cyclooxygenase pathway, and consist of PGD2, PGI2, PGE2, PGF2, and
thromboxane B2. PGs signal through G-protein coupled receptors, and individual PGs affect
allergic inflammation through different mechanisms according to the receptors with which
they are associated. In this review article, we have focused on the metabolism of the
cyclooxygenase pathway, and the distinct biological effect of each PG type on various cell …
via the cyclooxygenase pathway, and consist of PGD2, PGI2, PGE2, PGF2, and
thromboxane B2. PGs signal through G-protein coupled receptors, and individual PGs affect
allergic inflammation through different mechanisms according to the receptors with which
they are associated. In this review article, we have focused on the metabolism of the
cyclooxygenase pathway, and the distinct biological effect of each PG type on various cell …
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