[HTML][HTML] The DNA-mismatch repair enzyme hMSH2 modulates UV-B-induced cell cycle arrest and apoptosis in melanoma cells
M Seifert, SJ Scherer, W Edelmann, M Böhm… - Journal of Investigative …, 2008 - Elsevier
The mechanisms by which the post-replicative DNA mismatch repair (MMR) enzyme MSH2
is involved in the complex response mechanisms to UV damage are yet to be clarified. Here,
we show increased levels of MSH2 mRNA in malignant melanoma, metastases of
melanoma, and melanoma cell (MeWo) lines as compared with melanocytic nevi or primary
cultured benign melanocytes. UV-B treatment modulated MSH2 expression and silencing of
MSH2 gene expression using small interfering RNA technology regulated UV-B-induced cell …
is involved in the complex response mechanisms to UV damage are yet to be clarified. Here,
we show increased levels of MSH2 mRNA in malignant melanoma, metastases of
melanoma, and melanoma cell (MeWo) lines as compared with melanocytic nevi or primary
cultured benign melanocytes. UV-B treatment modulated MSH2 expression and silencing of
MSH2 gene expression using small interfering RNA technology regulated UV-B-induced cell …
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