The LRRK2 I2012T, G2019S and I2020T mutations are not common in patients with essential tremor
H Deng, WD Le, AL Davidson, WJ Xie, J Jankovic - Neuroscience letters, 2006 - Elsevier
Several mutations in the leucine-rich repeat kinase 2 gene (LRRK2) have been identified
both in familial and sporadic cases of Parkinson's disease (PD). G2019S, located at a kinase
(MAPKKK) domain, is the most common mutation in the LRRK2 gene in PD, Two adjacent
mutations (I2012T and I2020T) were mapped to the same domain suggesting shared
pathogenic mechanism of these mutations. Since phenotypes of PD overlap with essential
tremor (ET), we investigated LRRK2 G2019S, I2012T, and I2020T mutations in a cohort of …
both in familial and sporadic cases of Parkinson's disease (PD). G2019S, located at a kinase
(MAPKKK) domain, is the most common mutation in the LRRK2 gene in PD, Two adjacent
mutations (I2012T and I2020T) were mapped to the same domain suggesting shared
pathogenic mechanism of these mutations. Since phenotypes of PD overlap with essential
tremor (ET), we investigated LRRK2 G2019S, I2012T, and I2020T mutations in a cohort of …
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