The antidepressant effect of melatonin and fluoxetine in diabetic rats is associated with a reduction of the oxidative stress in the prefrontal and hippocampal cortices
In the past few years possible mechanisms that link diabetes and depression have been
found. One of these mechanisms is the increase in lipid peroxidation and decrease in
antioxidant activity in the hippocampal and prefrontal cortices, which are brain areas
involved in mood. The goal of the present study was to evaluate the effect of an
antidepressant and of an antioxidant on behavior and oxidative activity in brains of diabetic
rats. Rats rendered diabetic after a treatment with streptozotocin (STZ)(60 mg/kg) were …
found. One of these mechanisms is the increase in lipid peroxidation and decrease in
antioxidant activity in the hippocampal and prefrontal cortices, which are brain areas
involved in mood. The goal of the present study was to evaluate the effect of an
antidepressant and of an antioxidant on behavior and oxidative activity in brains of diabetic
rats. Rats rendered diabetic after a treatment with streptozotocin (STZ)(60 mg/kg) were …
[PDF][PDF] The antidepressant effect of melatonin and fluoxetine in
In the past few years possible mechanisms that link diabetes and depression have been
found. One of these mechanisms is the increase in lipid peroxidation and decrease in
antioxidant activity in the hippocampal and prefrontal cortices, which are brain areas
involved in mood. The goal of the present study was to evaluate the effect of an
antidepressant and of an antioxidant on behavior and oxidative activity in brains of diabetic
rats. Rats rendered diabetic after a treatment with streptozotocin (STZ)(60 mg/kg) were …
found. One of these mechanisms is the increase in lipid peroxidation and decrease in
antioxidant activity in the hippocampal and prefrontal cortices, which are brain areas
involved in mood. The goal of the present study was to evaluate the effect of an
antidepressant and of an antioxidant on behavior and oxidative activity in brains of diabetic
rats. Rats rendered diabetic after a treatment with streptozotocin (STZ)(60 mg/kg) were …
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