The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinate NF-ĸB subunits
The transcription factor NF-ĸB is a master regulator of the innate immune response and
plays a central role in inflammatory diseases by mediating the expression of pro-
inflammatory cytokines. Ubiquitination-triggered proteasomal degradation of DNA-bound NF-
ĸB strongly limits the expression of its target genes. Conversely, USP7 (deubiquitinase
ubiquitin-specific peptidase 7) opposes the activities of E3 ligases, stabilizes DNA-bound NF-
ĸB, and thereby promotes NF-ĸB–mediated transcription. Using gene expression and …
plays a central role in inflammatory diseases by mediating the expression of pro-
inflammatory cytokines. Ubiquitination-triggered proteasomal degradation of DNA-bound NF-
ĸB strongly limits the expression of its target genes. Conversely, USP7 (deubiquitinase
ubiquitin-specific peptidase 7) opposes the activities of E3 ligases, stabilizes DNA-bound NF-
ĸB, and thereby promotes NF-ĸB–mediated transcription. Using gene expression and …
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