The effect of bergamottin on diazepam plasma levels and P450 enzymes in beagle dogs
J Sahi, EL Reyner, JN Bauman… - Drug metabolism and …, 2002 - ASPET
Bergamottin, a furanocoumarin isolated from grapefruit juice, was investigated for the ability
to increase diazepam bioavailability and for its effect on cytochrome P450 (P450) enzymes
in the beagle dog liver and intestine. To study the effect of bergamottin on diazepam
pharmacokinetics, male beagle dogs were dosed with bergamottin (1 mg/kg) po 0 or 2 h
before po diazepam (10 mg). In a second experiment, bergamottin (0.1 mg/kg) was dosed iv
or po 1 h before po diazepam (10 mg). Plasma samples were collected over 24 h postdose …
to increase diazepam bioavailability and for its effect on cytochrome P450 (P450) enzymes
in the beagle dog liver and intestine. To study the effect of bergamottin on diazepam
pharmacokinetics, male beagle dogs were dosed with bergamottin (1 mg/kg) po 0 or 2 h
before po diazepam (10 mg). In a second experiment, bergamottin (0.1 mg/kg) was dosed iv
or po 1 h before po diazepam (10 mg). Plasma samples were collected over 24 h postdose …
