The emerging role of the Nrf2–Keap1 signaling pathway in cancer
MC Jaramillo, DD Zhang - Genes & development, 2013 - genesdev.cshlp.org
The Nrf2 (nuclear factor erythroid 2 [NF-E2]-related factor 2 [Nrf2])–Keap1 (Kelch-like
erythroid cell-derived protein with CNC homology [ECH]-associated protein 1) signaling
pathway is one of the most important cell defense and survival pathways. Nrf2 can protect
cells and tissues from a variety of toxicants and carcinogens by increasing the expression of
a number of cytoprotective genes. As a result, several Nrf2 activators are currently being
tested as chemopreventive compounds in clinical trials. Just as Nrf2 protects normal cells …
erythroid cell-derived protein with CNC homology [ECH]-associated protein 1) signaling
pathway is one of the most important cell defense and survival pathways. Nrf2 can protect
cells and tissues from a variety of toxicants and carcinogens by increasing the expression of
a number of cytoprotective genes. As a result, several Nrf2 activators are currently being
tested as chemopreventive compounds in clinical trials. Just as Nrf2 protects normal cells …
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