The long persistence of pyrrolizidine alkaloid-derived pyrrole-protein adducts in vivo: Kinetic study following multiple exposures of a pyrrolizidine alkaloid containing …
Y Chen, F Xiong, W Wang, K Jiang, X Ye, G Deng… - Toxicology Letters, 2020 - Elsevier
Gynura japonica (also named Tusanqi in Chinese) is used as a folk herbal medicine for
treating blood stasis or traumatic injury. However, hundreds of hepatic sinusoidal obstruction
syndrome (HSOS) cases have been reported after consumption of preparations made from
G. japonica because it contains large amounts of hepatotoxic pyrrolizidine alkaloids (PAs).
To date, blood pyrrole-protein adducts (PPAs) are suggested as biomarkers for the
diagnosis of PA-induced HSOS in clinics. However, the concentration of PPAs in the blood is …
treating blood stasis or traumatic injury. However, hundreds of hepatic sinusoidal obstruction
syndrome (HSOS) cases have been reported after consumption of preparations made from
G. japonica because it contains large amounts of hepatotoxic pyrrolizidine alkaloids (PAs).
To date, blood pyrrole-protein adducts (PPAs) are suggested as biomarkers for the
diagnosis of PA-induced HSOS in clinics. However, the concentration of PPAs in the blood is …
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