… known about the human zona pellucida. Finally, we will present genetic approaches available
in the mouse that could be used to further evaluate zona pellucida structure and function. …

… A heterozygous missense mutation in exon-3 of hZP1 was identified in an infertile patient …
Harvard Medical School, Roche Institute of Molecular Biology, and Icahn School of Medicine at …

… However, recent advances in molecular biology and genetics … Figure 1Genetic mutations
affecting female fertility. During … mouse ZP3 inhibits sperm binding to the zona pellucida and …

BACKGROUND Infertility is a major issue in human reproductive health, affecting an estimated
15% of couples worldwide. Infertility can result from disorders of sex development (DSD) …

… Fertility in female mammals, including mice and humans, is dependent on the presence of
a zona pellucida (ZP… Exons subject to mutations that caused infertility are marked by an X. …

… are unable to construct a ZP, ovulate few if any eggs, and are infertile. ZP1–3 have a … Mutations
in genes encoding ZPD proteins can result in severe human … Molecular biology of the cell …

… growing oocytes and females are infertile. There is no effect … , molecular genetic, and structural
aspects of mouse ZP genes … Furthermore, specific single mutations in the ZP domain can …

… that are associated with varying degrees of abnormal folliculogenesis and infertility. Female
mice with a Zp1-null mutation maintain a zona pellucida around their growing oocytes and …

… genetic analysis in the patients with female infertility due to abnormal zona pellucida and …
The mouse zona pellucida is composed of three glycoproteins—mZP1, mZP2, and mZP3. …

… We showed that the mutation reduced ZP2 expression and impeded … mouse model with
the mutation (Zp2 T541M ) using CRISPR-Cas9. Zp2 WT/T541M female mice had normal fertility …