… fumigatus PacC transcription factor (AFUA_3G11970) in pathogenicity we … fumigatus
clinical isolates CEA10 and ATCC46645 (Figure S1). Relative to non-mutated isolates, PacC null …

“For preparation of A. fumigatus culture supernatants, 106 spores/ml were grown in Dulbecco’s
Modified Eagle Medium (DMEM, Sigma) supplemented with 10% foetal bovine serum (…

… aspergillosis (IA) in immune compromised individuals. In the environment, A. … PacC-regulated
secreted factors, including proteases, is responsible for the reduction in epithelial invasion …

… by the pH-responsive transcription factor PacC. This study … severe manifestation is invasive
pulmonary aspergillosis (IPA) … that contributed to reduced epithelial invasion. For example, in …

… environmental ascomycete Aspergillus fumigatus serves as a … epithelial cells, which sets
the stage for invading the host … and FlbE [76], or the transcription factor Ace2 [77]. The fact that …

… that the pH-responsive transcription factor PacC was involved in the … The major route of 5FC
entry into A. … use of 5FC in murine models of aspergillosis, this drug is typically not applied in …

… causes the majority of cases of invasive aspergillosis, the … which governs the unfolded protein
response [27], and pacC, … to, invade, and damage the A549 pulmonary epithelial cell line …

… during lung invasion, has helped us to redefine the opportunistic pathogenesis of A. …
pH-responsive transcription factor (TF) PacC in Aspergillus pathogenicity, linked to epithelial …

… Invasive aspergillosis is initiated when Aspergillus fumigatus … Thus, the activation of these
transcription factor genes likely … fumigatus, enter cells by induced endocytosis (39, 40). We …

… Aspergillus niger is an exceptionally efficient producer of … niches, to disrupt the epithelia of
both mucosal and endothelial … nidulans pH-responsive transcription factor PacC thus plays …