The peptidyl-prolyl isomerase Pin1 regulates the stability of granulocyte-macrophage colony-stimulating factor mRNA in activated eosinophils

ZJ Shen, S Esnault, JS Malter - Nature immunology, 2005 - nature.com
Nature immunology, 2005nature.com
The infiltration, accumulation and degranulation of eosinophils in the lung represents a
hallmark of active asthma. In vivo or in vitro eosinophil activation triggers the secretion of the
antiapoptotic cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF). We
now identify Pin1, a cis-trans isomerase, as an essential component of the ribonucleoprotein
complex responsible for GM-CSF mRNA stabilization, cytokine secretion and the survival of
activated eosinophils. Pin1 regulated the association of the AU-rich element–binding …
Abstract
The infiltration, accumulation and degranulation of eosinophils in the lung represents a hallmark of active asthma. In vivo or in vitro eosinophil activation triggers the secretion of the antiapoptotic cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF). We now identify Pin1, a cis-trans isomerase, as an essential component of the ribonucleoprotein complex responsible for GM-CSF mRNA stabilization, cytokine secretion and the survival of activated eosinophils. Pin1 regulated the association of the AU-rich element–binding proteins AUF1 and hnRNP C with GM-CSF mRNA, accelerating or slowing decay, respectively. These data indicate Pin1 is a key mediator of GM-CSF production.
nature.com
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