The relevance of inter-and intrastrain differences in mice and rats and their implications for models of seizures and epilepsy
It is becoming increasingly clear that the genetic background of mice and rats, even in
inbred strains, can have a profound influence on measures of seizure susceptibility and
epilepsy. These differences can be capitalized upon through genetic mapping studies to
reveal genes important for seizures and epilepsy. However, strain background and
particularly mixed genetic backgrounds of transgenic animals need careful consideration in
both the selection of strains and in the interpretation of results and conclusions. For instance …
inbred strains, can have a profound influence on measures of seizure susceptibility and
epilepsy. These differences can be capitalized upon through genetic mapping studies to
reveal genes important for seizures and epilepsy. However, strain background and
particularly mixed genetic backgrounds of transgenic animals need careful consideration in
both the selection of strains and in the interpretation of results and conclusions. For instance …
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