The role of IL-2 in the activation and expansion of regulatory T-cells and the development of experimental autoimmune encephalomyelitis
M Rouse, M Nagarkatti, PS Nagarkatti - Immunobiology, 2013 - Elsevier
Multiple sclerosis (MS) is an autoimmune disease that affects∼ 400,000 people in the US. It
is a chronic, disabling disease with no cure, and the current treatment includes use of
immunosuppressive drugs that often exhibit toxic side effects. Thus, there is a pressing need
for alternate and more effective treatment strategies that target the components of
inflammatory cells. In recent years, regulatory T-cells (Tregs) have been found to play an
important role in preventing the development of autoimmunity. Thus, expansion of Tregs in …
is a chronic, disabling disease with no cure, and the current treatment includes use of
immunosuppressive drugs that often exhibit toxic side effects. Thus, there is a pressing need
for alternate and more effective treatment strategies that target the components of
inflammatory cells. In recent years, regulatory T-cells (Tregs) have been found to play an
important role in preventing the development of autoimmunity. Thus, expansion of Tregs in …
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