[HTML][HTML] The role of locus coeruleus nucleus TRPV1 receptors in the development and expression of morphine dependence
I Fatemi, Z Hadadianpour, F Fatehi… - Iranian Journal of …, 2019 - ncbi.nlm.nih.gov
Iranian Journal of Basic Medical Sciences, 2019•ncbi.nlm.nih.gov
Objective (s): This study investigated the role of locus coeruleus (LC) nucleus TRPV1
receptors (TRPV1r) in the expression and development of morphine physical dependence
by intra-LC administration of AMG9810 (selective TRPV1r antagonist) in male Wistar rats.
Materials and Methods: For assessing the development of morphine dependence,
AMG9810 (0.03 and 0.3 mM in 10% DMSO, 0.2 µl; intra-LC microinjection) was
administered before each morphine administration for seven continues days (once daily; 6 …
receptors (TRPV1r) in the expression and development of morphine physical dependence
by intra-LC administration of AMG9810 (selective TRPV1r antagonist) in male Wistar rats.
Materials and Methods: For assessing the development of morphine dependence,
AMG9810 (0.03 and 0.3 mM in 10% DMSO, 0.2 µl; intra-LC microinjection) was
administered before each morphine administration for seven continues days (once daily; 6 …
Abstract
Objective (s):
This study investigated the role of locus coeruleus (LC) nucleus TRPV1 receptors (TRPV1r) in the expression and development of morphine physical dependence by intra-LC administration of AMG9810 (selective TRPV1r antagonist) in male Wistar rats.
Materials and Methods:
For assessing the development of morphine dependence, AMG9810 (0.03 and 0.3 mM in 10% DMSO, 0.2 µl; intra-LC microinjection) was administered before each morphine administration for seven continues days (once daily; 6, 16, 26, 36, 46, 56, and 66 mg/kg; sc). Furthermore, for evaluating the expression of morphine dependence, a single dose of AMG9810 (0.03 and 0.3 mM in 10% DMSO, 0.2 µl; intra-LC microinjection) was administered to morphine-dependent rats on day 8 of the experiment.
Results:
Obtained data demonstrated that co-administration of TRPV1r antagonist with morphine reduced the development of morphine withdrawal syndrome somatic signs induced by naloxone. Moreover, single intra-LC administration of TRPV1r antagonist on the final day of the examination period significantly decreased the expression of some signs of morphine withdrawal in rats.
Conclusion:
The results showed that LC TRPV1r might be participating in the expression and development of morphine dependence.
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