BACKGROUND CONTEXT: Although autogenous bone is still considered to be the gold
standard graft material for promoting spinal fusion, other bone graft substitutes have been
developed in an attempt to improve arthrodesis rates and avoid the complications
associated with the procurement of autograft. The bone morphogenetic proteins (BMPs)
represent a family of osteoinductive growth factors that are known to stimulate the
osteoblastic differentiation of stem cells. Osteogenic protein-1 (OP-1) Putty is a commercially …

Study Design. Randomized controlled trial comparing OP-1 (rhBMP-7) with iliac crest
autograft in patients with symptomatic degenerative spondylolisthesis and spinal stenosis
treated with decompression and uninstrumented posterolateral arthrodesis. Objective. To
determine the safety and the clinical and radiographic efficacy of OP-1 (rhBMP-7) Putty as
compared with an iliac crest bone autograft control in uninstrumented, single-level
posterolateral spinal arthrodesis. Summary of Background Data. Preclinical and preliminary …