The secretome of a parasite in its definitive host can be considered to be its genome in trans,
to the extent that secreted products encoded by the parasite fulfill their function in the host
milieu. The 'extended phenotype'of the filarial parasite, Brugia malayi, is of particular interest
because of the evidence that infection results in potent down-modulation of the host immune
response. We collected B. malayi 'excretory–secretory'(BES) proteins from adult parasites
and using a combination of shotgun LC–MS/MS and 2D gel electrophoresis, identified 80 B …