The transient receptor potential vanilloid-responsive 1 and 4 cation channels: role in neuronal osmosensing and renal physiology
DM Cohen - Current opinion in nephrology and hypertension, 2007 - journals.lww.com
… A number of pivotal observations underscore the primary importance of transient receptor
potential channels in systemic osmoregulation and their involvement constitutes the focus of
this review. Recent data suggest that transient receptor potential vanilloid-responsive 4 is a
central sensor or effector of systemic hypotonicity, whereas an unidentified variant of
transient receptor potential vanilloid-responsive 1 potentially serves an analogous role in
systemic hypertonicity. … Sensing of aberrations in systemic water balance takes place in …
potential channels in systemic osmoregulation and their involvement constitutes the focus of
this review. Recent data suggest that transient receptor potential vanilloid-responsive 4 is a
central sensor or effector of systemic hypotonicity, whereas an unidentified variant of
transient receptor potential vanilloid-responsive 1 potentially serves an analogous role in
systemic hypertonicity. … Sensing of aberrations in systemic water balance takes place in …
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