Tissue distribution and excretion of resveratrol in rat after oral administration of Polygonum cuspidatum extract (PCE)

D Wang, Y Xu, W Liu - Phytomedicine, 2008 - Elsevier
PURPOSE: Polygonum cuspidatum extract as a traditional Chinese medicine is extracted
from the dried rhizome and root of Polygonum cuspidatum Sieb. et Zucc. Resveratrol is one
of its active components. Studies were performed in rats to define the tissue distribution and
excretion of resveratrol in urine and bile, and to characterize (if possible) any metabolites of
resveratrol observed in tissues after ig 20mg/kg Polygonum cuspidatum extract. METHOD:
For tissue distribution studies, tissues (300mg) were homogenized and centrifuged with …
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