In fungi, ambient pH sensing involves the activation of the Pal/PacC signalling pathway. In
the dermatophyte Trichophyton rubrum, pH-dependent secretion of keratinases, which are
major virulence determinants, is affected by disruption of the pacC gene. Here, the
transcription profiling of the genes coding for N-and O-linked mannosyltransferases,
enzymes involved in protein glycosylation, was evaluated in T. rubrum in response to
disruption of the pacC gene and growth in keratin, glucose, and glucose plus glycine. We …