[HTML][HTML] Transcriptomic analysis of smooth versus rough Brucella melitensis Rev. 1 vaccine strains reveals insights into virulence attenuation
M Salmon-Divon, D Kornspan - International Journal of Medical …, 2020 - Elsevier
Brucella melitensis Rev. 1 is the live attenuated Elberg-originated vaccine strain of the
facultative intracellular Brucella species, and is widely used to control brucellosis in small
ruminants. However, Rev. 1 may cause abortions in small ruminants that have been
vaccinated during the last trimester of gestation, it is pathogenic to humans, and it induces
antibodies directed at the O-polysaccharide (O-PS) of the smooth lipopolysaccharide, thus
making it difficult to distinguish between vaccinated and infected animals. Rough Brucella …
facultative intracellular Brucella species, and is widely used to control brucellosis in small
ruminants. However, Rev. 1 may cause abortions in small ruminants that have been
vaccinated during the last trimester of gestation, it is pathogenic to humans, and it induces
antibodies directed at the O-polysaccharide (O-PS) of the smooth lipopolysaccharide, thus
making it difficult to distinguish between vaccinated and infected animals. Rough Brucella …
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