Translational study searching for synergy between glycopyrronium and indacaterol
M Cazzola, L Calzetta, A Segreti… - COPD: Journal of …, 2015 - Taylor & Francis
We aimed to explore whether the acute bronchodilation induced by indacaterol 150 μg and
glycopyrronium bromide 50 μg is additive or synergistic with respect to monocomponents by
testing the type of effect ex vivo on isolated human bronchi and then in vivo in COPD
patients. Both indacaterol and glycopyrronium caused a concentration-dependent relaxation
of human isolated bronchial tissues sub-maximally pre-contracted with acetylcholine;
glycopyrronium was significantly more potent than indacaterol. The analysis of data using …
glycopyrronium bromide 50 μg is additive or synergistic with respect to monocomponents by
testing the type of effect ex vivo on isolated human bronchi and then in vivo in COPD
patients. Both indacaterol and glycopyrronium caused a concentration-dependent relaxation
of human isolated bronchial tissues sub-maximally pre-contracted with acetylcholine;
glycopyrronium was significantly more potent than indacaterol. The analysis of data using …
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