Triclosan reduces microsomal prostaglandin E synthase‐1 expression in human gingival fibroblasts
M Mustafa, B Wondimu… - Journal of clinical …, 2005 - Wiley Online Library
Objective: The effect of triclosan (2, 4, 4′‐trichloro‐2′‐hydroxydiphenyl ether) on the
expression of cyclooxygenase‐2 (COX‐2) and microsomal prostaglandin E synthase‐1
(mPGES‐1) and on the translocation of the nuclear factor‐κB (NF‐κB) in relation to
prostaglandin E2 (PGE2) production was investigated in human gingival fibroblasts
challenged with tumor necrosis factor α (TNFα). Methods: Fibroblasts were established from
gingival biopsies obtained from six children. COX‐2 mRNA and protein expression was …
expression of cyclooxygenase‐2 (COX‐2) and microsomal prostaglandin E synthase‐1
(mPGES‐1) and on the translocation of the nuclear factor‐κB (NF‐κB) in relation to
prostaglandin E2 (PGE2) production was investigated in human gingival fibroblasts
challenged with tumor necrosis factor α (TNFα). Methods: Fibroblasts were established from
gingival biopsies obtained from six children. COX‐2 mRNA and protein expression was …
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