Theranostic nanoparticles can deliver therapeutic agents as well as diverse imaging agents
to tumors. The enhanced permeation and retention (EPR) effect is regarded as a crucial
mechanism for the tumor-targeted delivery of nanoparticles. Although a large number of
studies of the EPR effect of theranostic nanoparticles have been performed, the effect of the
change in the body size of the host on the EPR effect is not fully understood. In this regard,
comparative research is needed on the behavior of nanoparticles in large animals for …