Ubiquitin‐positive tau‐negative intraneuronal inclusions in dementia with motor neuron disease: The 50th Anniversary of Japanese Society of Neuropathology
K Okamoto - Neuropathology, 2010 - Wiley Online Library
K Okamoto
Neuropathology, 2010•Wiley Online LibraryWe first reported ubiquitin‐positive tau‐negative intraneuronal inclusions in the
hippocampal granular cell layer and entorhinal cortices in patients with amyotrophic lateral
sclerosis (ALS). We then found that those inclusions occur frequently in patients with
presenile dementia and motor neuron disease. The ultrastructure of the inclusions consists
mainly of granules with a few filaments. In 2006, TDP‐43 was identified as a major
component of the inclusions specific for frontotemporal lobar degeneration and ALS. Here …
hippocampal granular cell layer and entorhinal cortices in patients with amyotrophic lateral
sclerosis (ALS). We then found that those inclusions occur frequently in patients with
presenile dementia and motor neuron disease. The ultrastructure of the inclusions consists
mainly of granules with a few filaments. In 2006, TDP‐43 was identified as a major
component of the inclusions specific for frontotemporal lobar degeneration and ALS. Here …
We first reported ubiquitin‐positive tau‐negative intraneuronal inclusions in the hippocampal granular cell layer and entorhinal cortices in patients with amyotrophic lateral sclerosis (ALS). We then found that those inclusions occur frequently in patients with presenile dementia and motor neuron disease. The ultrastructure of the inclusions consists mainly of granules with a few filaments. In 2006, TDP‐43 was identified as a major component of the inclusions specific for frontotemporal lobar degeneration and ALS. Here, we review the current knowledge regarding ubiquitin‐positive tau‐negative intraneuronal inclusions.
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