Variability in methotrexate serum and cerebrospinal fluid pharmacokinetics in children with acute lymphocytic leukemia: relation to assay methodology and …
H Seidel, A Andersen, JT Kvaløy, R Nygaard, PJ Moe… - Leukemia research, 2000 - Elsevier
Methotrexate (MTX) steady state concentrations were evaluated in 42 children who had
received high-dose infusions (6–8 g/m2) for acute lymphocytic leukemia. Concentrations in
serum and cerebrospinal fluid (CSF) measured by immunoassay were found to be highly
variable. Reanalysis by a reference high-pressure liquid chromatography method ruled out
analytical factors as a source of this variability. The correlation coefficient between the
analytical methods was 0.77 for the serum data and 0.88 for the CSF data. The variability of …
received high-dose infusions (6–8 g/m2) for acute lymphocytic leukemia. Concentrations in
serum and cerebrospinal fluid (CSF) measured by immunoassay were found to be highly
variable. Reanalysis by a reference high-pressure liquid chromatography method ruled out
analytical factors as a source of this variability. The correlation coefficient between the
analytical methods was 0.77 for the serum data and 0.88 for the CSF data. The variability of …
