Visualizing and quantifying oxidized protein thiols in tissue sections: a comparison of dystrophic mdx and normal skeletal mouse muscles
T Iwasaki, J Terrill, T Shavlakadze, MD Grounds… - Free Radical Biology …, 2013 - Elsevier
Reactive oxygen species (ROS) are not only a cause of oxidative stress in a range of
disease conditions but are also important regulators of physiological pathways in vivo. One
mechanism whereby ROS can regulate cell function is by modification of proteins through
the reversible oxidation of their thiol groups. An experimental challenge has been the
relative lack of techniques to probe the biological significance of protein thiol oxidation in
complex multicellular tissues and organs. We have developed a sensitive and quantitative …
disease conditions but are also important regulators of physiological pathways in vivo. One
mechanism whereby ROS can regulate cell function is by modification of proteins through
the reversible oxidation of their thiol groups. An experimental challenge has been the
relative lack of techniques to probe the biological significance of protein thiol oxidation in
complex multicellular tissues and organs. We have developed a sensitive and quantitative …
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