[HTML][HTML] p115 RhoGEF activates the Rac1 GTPase signaling cascade in MCP1 chemokine–induced vascular smooth muscle cell migration and proliferation
NK Singh, J Janjanam, GN Rao - Journal of Biological Chemistry, 2017 - ASBMB
Although the involvement of Rho proteins in the pathogenesis of vascular diseases is well
studied, little is known about the role of their upstream regulators, the Rho guanine
nucleotide exchange factors (RhoGEFs). Here, we sought to identify the RhoGEFs involved
in monocyte chemotactic protein 1 (MCP1)–induced vascular wall remodeling. We found
that, among the RhoGEFs tested, MCP1 induced tyrosine phosphorylation of p115 RhoGEF
but not of PDZ RhoGEF or leukemia-associated RhoGEF in human aortic smooth muscle …
studied, little is known about the role of their upstream regulators, the Rho guanine
nucleotide exchange factors (RhoGEFs). Here, we sought to identify the RhoGEFs involved
in monocyte chemotactic protein 1 (MCP1)–induced vascular wall remodeling. We found
that, among the RhoGEFs tested, MCP1 induced tyrosine phosphorylation of p115 RhoGEF
but not of PDZ RhoGEF or leukemia-associated RhoGEF in human aortic smooth muscle …
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