IN the hereditary blistering condition epidermolysis bullosa simplex, the skin blisters on
trauma following rupture of epidermal basal cells. Clinical variations range from severely …

Epidermolysis bullosa simplex (EBS) is a group of epidermal blistering diseases almost
invariably transmitted as a dominant trait, which has recently been shown to arise from …

Previously we demonstrated that transgenic mice expressing mutant basal epidermal keratin
genes exhibited a phenotype resembling a group of autosomal dominant human skin …

Keratins are the major structural proteins of the epidermis. Recently, it was discovered that
point mutations in the epidermal keratins can lead to the blistering skin diseases …

Since their discovery, the function of intermediate filaments (IFs) has remained obscure. In
skin, epidermal cells have extensive cytoskeletal architectures of IFs, composed of type I and …

Previously we demonstrated that transgenic mice expressing a mutant keratin in the basal
layer of their stratified squamous epithelia exhibited a phenotype bearing resemblance to a …

The importance of keratins and other intermediate filaments in the maintenance of tissue
structure is emphasized by the discovery that many hereditary skin-blistering diseases are …

Blisters following minor trauma characterize epidermolysis bullosa, a group of hereditary
diseases of the skin. In the simplex type, epidermal basal cells are fragile, and mutations of …

Keratins are cytoskeletal filament-forming proteins found in skin and other epithelial (sheet)
tissues (Table 1). Keratins (type I and II), and other highly related (types III–VI) intermediate …

Keratins are the type I and II intermediate filament proteins which form a cytoskeletal network
within all epithelial cells. They are expressed in pairs in a tissue-and differentiation-specific …