We have developed a novel 3-D gel reconstituted with major extracellular matrix (ECM)
glycoproteins to follow the dynamics of migration of human T cells locomoting, in real-time …

Cell migration may depend on integrin‐mediated adhesion to and deadhesion from
extracellular matrix ligands. This concept, however, has not yet been confirmed for T …

The role of chemokines and their interactions with extracellular matrix components (ECM) or
the capacity of T cells to migrate into and accumulate within three‐dimensional (3D) …

The locomotion of T lymphocytes within 3-D extracellular matrix (ECM) is a highly dynamic
and flexible process following the principles of ameboid movement. Ameboid motility is …

The migration of T cells into extravascular sites of inflammation is regulated by information
derived from the molecular structure of the invaded tissue and from chemokine and cytokine …

The migration of T-cell subsets within peripheral tissues is characteristic of inflammation and
immunoregulation. In general, the lymphocyte migratory response is assumed directional …

Cell motility requires the temporal and spatial coordination of the actin cytoskeleton with cell-
matrix adhesions. Since their discovery more than 20 years ago, integrins have been at the …

Stromal cells may regulate the recruitment and behaviour of leukocytes during an
inflammatory response, potentially through interaction with the endothelial cells (EC) and the …

We evaluated three different quantitative evaluation methods for lymphocyte locomotion in
three-dimensional collagen gels:(1) the length of the two-dimensional migration path …

Cell migration on two-dimensional (2D) substrates follows entirely different rules than cell
migration in three-dimensional (3D) environments. This is especially relevant for leukocytes …