Cutaneous malignant melanoma is a life-threatening cancer with poor prognosis due to a
high metastasis potential. The main obstacle in treatment of metastatic melanoma is the …

Metastatic melanomas are often resistant to chemotherapy. To study whether the p53
mutational status affects chemosensitivity, we compared the responses to chemotherapy of …

Background p53, a commonly mutated gene in human cancers, participates in cell cycle
arrest, DNA repair and apoptosis. A small pharmacological compound, CP‐31398, was …

p53, A tumor suppressor gene, has been documented as the most frequently mutated gene
in human cancers including non-melanoma skin tumors. It has been controversial whether …

Melanoma cells rarely contain mutant p53 and hardly undergo apoptosis by wild-type p53.
By using recombinant adenoviruses that express p53 or p53-related p51A or p73β, we …

Mutations in ras and p53 are the most prevalent mutations found in human nonmelanoma
skin cancers. Although some p53 mutations cause a loss of function, most result in …

Metastatic melanoma is an aggressive disease, despite recent improvements in therapy.
Eradicating all melanoma cells even in drug-sensitive tumors is unsuccessful in patients …

Background Metastatic melanoma represents a major clinical problem. Its incidence
continues to rise in western countries and there are currently no curative treatments. While …

We investigated whether p53 plays a role in UV induced apoptosis in melanoma. UVA and
UVB induced apoptosis in dose dependent and wild type p53 melanoma cells were much …

Background The treatment of melanoma, an aggressive, chemo-resistant skin cancer
characterized by rapid metastasis and a poor prognosis, requires the development of …