Background: Infertility is described as not receiving pregnancy despite unprotected and
regular sexual intercourse in a 1 yr period. It is detected by 15% of the couples. Male and …

Background: Infertility is described as inability of a couple to conceive after a period of one
year regular unprotected intercourse. About 10%-15% of couples experience some form of …

Ion channels regulate the membrane potential and intracellular ionic concentration and thus
serve a central role in various cellular processes. Several ion channels have been identified …

Interest in ion channels as drug targets for contraception has grown with the realization that
certain ion channel subunits are located exclusively in sperm. Selective knockdown of ion …

Spermatogenesis is a complex and well-orchestrated process, in which spermatogonial
stem cells undergo multiple rounds of DNA replication, meiosis, and cellular differentiation to …

BACKGROUND Intensive research on sperm ion channels has identified members of
several ion channel families in both mouse and human sperm. Gene knock-out studies have …

A clinically significant proportion of couples experience difficulty in conceiving a child. In
about half of these cases male infertility is the cause and often genetic factors are involved …

Channel activities, particularly those of calcium channels, have vital roles in the process of
sperm maturation, motility and sperm-egg interaction. A group of the recently discovered ion …

CATSPER1 and CATSPER2 are two cation channel-like proteins exclusively expressed in
the testis and essential for normal sperm motility and male fertility. Using in silico subtraction …

Aim: To investigate the distribution of cation channel of sperm 1 (CATSPER1) protein and
the presence of CATSPER1 mRNA in human testis and ejaculated spermatozoa. The …