One of the most complex forms of congenital heart disease (CHD) involving single ventricle
physiology is hypoplastic left heart syndrome (HLHS), characterized by underdevelopment …

For more than a decade, stem cell therapy has been the focus of intensive efforts for the
treatment of adult heart disease, and now has promise for treating the pediatric population …

Dramatic evolution in medical and catheter interventions and complex surgeries to treat
children with congenital heart disease (CHD) has led to a growing number of patients with a …

Congenital heart disease remains one of the most frequently diagnosed congenital diseases
of the newborn, with hypoplastic left heart syndrome (HLHS) being considered one of the …

Hypoplastic left heart syndrome (HLHS), the most severe and common form of single
ventricle congenital heart lesions, is characterized by hypoplasia of the mitral valve, left …

CDC treatment but, instead, natural remodeling of the ventricle over time after surgical
intervention. Finally, the CDC treatment failed to affect mortality, which likely reflects the …

The current standard of care for neonates with hypoplastic left heart syndrome (HLHS)
includes a series of cardiac operations culminating in a complete cavopulmonary …

Over the past 2 decades, early diagnosis, improvements of preoperative care, and the
evolution of catheter interventions and surgical procedures have led to notable progress in …

Congenital heart disease occurs in 1% of liveborn infants, making it the most common birth
defect worldwide. Many of these children develop heart failure. In addition, both genetic and …

A focus on preemptive cardiac regeneration in the pediatric setting may offer new insights
into the timing of surgery, location of cell-based delivery, and type of cell-based regeneration …