Unc119 is an adaptor protein that is involved in the development of the vertebrate nervous
system. We have shown that Unc119 stimulates the induction of α-smooth muscle actin (α …

Members of the UNC-5 protein family are transmembrane receptors for UNC-6/netrin
guidance cues. To analyze the functional roles of different UNC-5 domains, we sequenced …

Previous studies have shown that the UNC-45 protein of C. elegans is required for normal
thick filament assembly, binds Hsp90 and the myosin head, and shows molecular …

Myofibroblasts are known to play key roles in wound healing and fibrosis. They are thought
to arise de novo from fibroblasts, and are characterized by induction of α–smooth muscle …

Few studies have addressed the importance of vascular remodeling in the lung during the
development of bleomycin-induced pulmonary fibrosis (BPF). For fibroplasia and deposition …

The chemokine, CXCL10, and its cognate receptor, CXCR3, are important mediators of the
pathobiology of lung fibrosis. Macrophages are a known source of CXCL10, but their …

The Th2 bias is a hallmark of allergic diseases. In this study, we show that the Th1 versus
Th2 balance and the development of allergic asthma are strongly affected by the signaling …

Pulmonary fibrosis is a fatal condition characterized by fibroblast and myofibroblast
proliferation and collagen deposition. TGF-β plays a pivotal role in the development of …

Background Unc-45 is a myosin chaperone and a Hsp90 co-chaperone that plays a key role
in muscle development. Genetic and biochemical studies in C. elegans have demonstrated …

Pulmonary fibrosis is an enigmatic and devastating disease with few treatment options, now
thought to result from abnormal wound healing in the lung in response to injury. We have …