Recent studies have suggested that wild-type p53 blocks cell cycle progression near the G1-
S boundary and is involved in both differentiation and apoptosis in many types of cells …

Tumor-associated mutant forms of p53 can exert an antiapoptotic gain of function activity,
which probably confers a selective advantage upon tumor cells harboring such mutations …

Fas/APO-1 is a cell surface protein known to trigger apoptosis upon specific antibody
engagement. Because wild-type p53 can activate transcription as well as induce apoptosis …

The p53 mutant 143Ala is a human temperature-sensitive mutant with two conformational
states. To definitively determine whether the Fas signal transduction pathway and the …

Recent evidence suggests an intriguing link between p53 and the Fas pathway. To evaluate
this association further, we utilized a recombinant adenoviral vector (AdWTp53) to …

Apoptosis is a mechanism of cell death that occurs in normal development and on the
regulation of vertebrate tissues and organ cellularity. Neurons undergo p53-dependent and …

Although p53 inactivation is implicated as a mechanism to explain diminished apoptotic
response, it is clear that tumor cells that possess transcriptionally functional p53 can also be …

The tumor suppressor p53 exerts its antioncogenic effects in cells chiefly by regulating their
progression through the cell cycle and by inducing cell death. It has been claimed that p53 …

p53 is a tumor suppressor protein that induces apoptosis at least in part through its ability to
act as a sequence-specific transactivator. This work reports that intron 1 of the mouse Fas …

The gene coding for p53, a suppressor of malignant growth, is induced by various stress
factors that cause appearance of the hereditarily pathologic cells. One of important p53 …